Serena, Michelle, Kenya, and Lynette have known each other since they were small children. They grew up in different neighborhoods, but they also grew up in the same church (which is how they first met), and while they each attended different colleges, they never lost touch with each other. Now many years later, at age forty, they are still best friends forever and they meet for lunch on the first Saturday of every month, but their lives couldn't be more different.